Monitoring and adjusting calibrations of various satellite imagers is often exacerbated by differences in their spectral response functions (SRFs). To help account for spectral disparities among satellite imagers, a web-based spectral band difference correction calculator has been developed to characterize the relationship between a specified pair of satellite imager channels in the hyperspectral wavelength range of 240–1750 nm. These spectral band adjustment factors (SBAFs) are derived by convolving hyperspectral data from the SCIAMACHY instrument with the SRFs of a reference and target sensor. The SBAF tool can be used for all combinations of instrument/channel pairs over predefined Earth spectra, intercalibration domains, or user-defined spatial domains. Options are available to the user whereby SBAFs can be subsetted by time, angle, and/or precipitable water content. To evaluate the relative spectral calibration of SCIAMACHY, comparisons of SBAFs derived from SCIAMACHY, Hyperion, and Global Ozone Monitoring Experiment-2 (GOME-2) were performed. Using observations over the Libya 4 desert pseudoinvariant calibration site, it is shown that SCIAMACHY-based SBAFs are within 0.1%–0.3% of SBAFs derived from Hyperion or GOME-2. This result implies that spectral calibration differences, i.e., the calibration uncertainties of SCIAMACHY relative to other potential spectral sources, have a minor impact on the SBAF compared with the influence of effective parameter-based subsetting. The SCIAMACHY instrument is most suited for calculating the SBAFs, given its high spectral resolution, broad spectral range, and nearly continuous global availability. The calibration community will find this SBAF tool useful for mitigating the SRF differences that can complicate the comparison and intercalibration of visible and near-infrared sensors.