Accurate knowledge of cloud optical properties, such as extinction-to-backscatter ratio and depolarization ratio, can have a significant impact on the quality of cloud extinction retrievals from lidar systems because parameterizations of these variables are often used in nonideal conditions to determine cloud phase and optical depth. Statistics and trends of these optical parameters are analyzed for 4 yr (2003–07) of cloud physics lidar data during five projects that occurred in varying geographic locations and meteorological seasons. Extinction-to-backscatter ratios (also called lidar ratios) are derived at 532 nm by calculating the transmission loss through the cloud layer and then applying it to the attenuated backscatter profile in the layer, while volume depolarization ratios are computed using the ratio of the parallel and perpendicular polarized 1064-nm channels. The majority of the cloud layers yields a lidar ratio between 10 and 40 sr, with the lidar ratio frequency distribution centered at 25 sr for ice clouds and 16 sr for altocumulus clouds. On average, for ice clouds the lidar ratio slightly decreases with decreasing temperature, while the volume depolarization ratio increases significantly as temperatures decrease. Trends for liquid water clouds (altocumulus clouds) are also observed. Ultimately, these observed trends in optical properties, as functions of temperature and geographic location, should help to improve current parameterizations of extinction-to-backscatter ratio, which in turn should yield increased accuracy in cloud optical depth and radiative forcing estimates.