Using thermal infrared (TIR) data from multiple instruments and platforms for analysis of an entire active volcanic system is becoming more common with the increasing availability of new data. However, the accuracy and uncertainty associated with these combined datasets are poorly constrained over the full range of eruption temperatures and possible volcanic products. Here, four TIR datasets acquired over active lava surfaces are compared to quantify the uncertainty, accuracy, and variability in derived surface radiance, emissivity, and kinetic temperature. These data were acquired at Kı̄lauea volcano in Hawai’i, USA, in January/February 2017 and 2018. The analysis reveals that spatial resolution strongly limits the accuracy of the derived surface thermal properties, resulting in values that are significantly below the expected values for molten basaltic lava at its liquidus temperature. The surface radiance is ~2400% underestimated in the orbital data compared to only ~200% in ground-based data. As a result, the surface emissivity is overestimated and the kinetic temperature is underestimated by at least 30% and 200% in the airborne and orbital datasets, respectively. A thermal mixed pixel separation analysis is conducted to extract only the molten fraction within each pixel in an attempt to mitigate this complicating factor. This improved the orbital and airborne surface radiance values to within 15% of the expected values and the derived emissivity and kinetic temperature within 8% and 12%, respectively. It is, therefore, possible to use moderate spatial resolution TIR data to derive accurate and reliable emissivity and kinetic temperatures of a molten lava surface that are comparable to the higher resolution data from airborne and ground-based instruments. This approach, resulting in more accurate kinetic temperature and emissivity of the active surfaces, can improve estimates of flow hazards by greatly improving lava flow propagation models that rely on these data.