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Arctic sea ice is declining rapidly and its annual ice extent minima reached record lows twice during the last decade. Large environmental and socioeconomic implications related to sea ice reduction in a warming world necessitate realistic simulations of the Arctic climate system, not least to formulate relevant environmental policies on an international scale. However, despite considerable progress in the last few decades, future climate projections from numerical models still exhibit the largest uncertainties over the polar regions. The lack of sufficient observations of essential climate variables is partly to blame for the poor representation of key atmospheric processes, and their coupling to the surface, in climate models. Observations from the hyper spectral Atmospheric Infrared Sounder (AIRS) instrument on board National Aeronautics and Space Administration (NASA)'s Aqua satellite are contributing toward improved understanding of the vertical structure of the atmosphere over the poles since 2002, including the lower troposphere. This part of the atmosphere is especially important in the Arctic, as it directly impacts sea ice and its short-term variability. Although in situ measurements provide invaluable ground truth, they are spatially and temporally inhomogeneous and sporadic over the Arctic. A growing number of studies are exploiting AIRS data to investigate the thermodynamic structure of the Arctic atmosphere, with applications ranging from understanding processes to deriving climatologies; all of which are also useful to test and improve parameterizations in climate models. As the AIRS data record now extends more than a decade, a select few of many such noteworthy applications of AIRS data over this challenging and rapidly changing landscape are highlighted here.